Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. >= 1.10 Index Positive for IgG antibody to HSV type 1 glycoprotein G. HSV-2 IgG <= 0.89 Index Negative for IgG antibody to HSV type 2 glycoprotein G. Repeat testing in 4-6 weeks may be helpful. Understanding the complex functions of these HSV proteins may be essential for successful development of vaccines for HSV. Unable to load your collection due to an error Repeat testing, or testing by a different method, may be indicated in some settings (eg, patients with low likelihood of HSV infection).To evaluate the accuracy of the BioPlex HSV assay, 505 prospective serum samples were tested by EIA (HerpeSelect, Focus Diagnostics, Cypress, CA) and the BioPlex HSV-1/2 IgG assay.

Print 2016 Nov 15.Cairns TM, Ditto NT, Atanasiu D, Lou H, Brooks BD, Saw WT, Eisenberg RJ, Cohen GH.J Virol. Most HSV serology assays, however, are not type-specific. Free PMC article In addition, the results of HSV type-specific IgG testing is sometimes used during pregnancy to identify risks of congenital HSV disease and allow for focused counseling prior to delivery.Negative (reported as positive, negative, or equivocal)This assay detects IgG-class antibodies to type-specific herpes simplex virus (HSV) glycoprotein G (gG), and may allow for the differentiation of infection caused by HSV types 1 and 2. Free PMC article Binnicker MJ, Jespersen DJ, Harring JA: Evaluation of three multiplex flow immunoassays to enzyme immunoassay for the detection and differentiation of IgG-class antibodies to herpes simplex virus types 1 and 2. Four viral surface glycoproteins (gB, gD, gH and gL) are required. doi: 10.1371/journal.ppat.1007914. 2016 Oct 28;90(22):10321-10328. doi: 10.1128/JVI.01714-16. This review summarises the known structure and function of each of these essential viral envelope glycoproteins, and explores what is known about their close cooperation with each other in mediating cellular membrane fusion.

This review summarises the known structure and function of each of these essential viral … Not a stand-alone test. There is a considerable homology between HSV-1 and HSV-2 antigens, so that antibodies formed against either virus are highly cross-reactive. However, recent studies have demonstrated that the same proteins also play a key role in initiating the early innate immune response to HSV. There is no mechanism, therefore, for testing for HSV-1 without simultaneously testing for HSV-2. J Virol. J Clin Microbiol 1998;36:294-2953.

This assay detects IgG-class antibodies to type-specific herpes simplex virus (HSV) glycoprotein G (gG), and may allow for the differentiation of infection caused by HSV types 1 and 2. All Rights Reserved. This assay is based on purified recombinant glycoprotein G-1 and is specific for type 1 antibodies. Ashley RL, Wu L, Pickering JW, et al: Premarket evaluation of a commercial glycoprotein G-based enzyme immunoassay for herpes simplex virus type-specific antibodies. Intervals are Mayo-derived, unless otherwise designated.

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2019 Jul 30;20(15):3715. doi: 10.3390/ijms20153715.Ye X, Gui X, Freed DC, Ku Z, Li L, Chen Y, Xiong W, Fan X, Su H, He X, Rustandi RR, Loughney JW, Ma N, Espeseth AS, Liu J, Zhu H, Wang D, Zhang N, Fu TM, An Z.PLoS Pathog. Envelope glycoprotein that forms spikes at the surface of virion envelope. It is suggested that, following gD binding to one of its entry receptors, membrane fusion is mediated by gB and the heterodimer gH/gL. Order in conjunction with Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA ().Because glycoprotein antibodies may require 3-6 months to form, follow-up testing is recommended to confirm a negative IgG glycoprotein result in the context of positive HSV Types 1 or 2 antibody results. In rare cases it also leads to herpes keratitis and herpes simplex encephalitis, which can progress to blindness and death, respectively 1, 2.Primary HSV‐1 infection usually occurs early in life and results in a latent but lifelong infection with a seroprevalence of 50–80% … 2015 Dec 11;7(12):6552-69. doi: 10.3390/v7122957.Viruses. Unable to load your delegates due to an error Four viral surface glycoproteins (gB, gD, gH and gL) are required. N Engl J Med 1997;337:509-5154. Print 2019 Aug 1.Adv Exp Med Biol. The glycoproteins serve an important role as targets of adaptive immunity. Herpes Simplex Virus-1 is a common infectious agent, but the precise detail of entry and infection of cells has only now begun to be clarified. Suggests clinical disorders or settings where the test may be helpfulDiscusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory testDescribes reference intervals and additional information for interpretation of test results.